Calcium homeostasis in neuroinflammation and -degeneration: New targets for therapy of multiple sclerosis?

This initiative aims to discover some of the fundamental principles by which calcium influences the disease processes of neuroinflammation and –degeneration.

We apply an approach interlinking immunological and neurobiological aspects by focussing on disturbances of calcium homeostasis and dysfunction of channels related to calcium fluxes. Since different cell types involved in the pathophysiology of MS, including cells of the immune system (lymphocytes and microglia), the neurovascular unit (endothelial cells and astrocytes) and neurons, critically depend on calcium homeostasis, our aim is to recognize cell-type specific as well as general patterns of calcium dysregulation.