The role of transient receptor potential channels in neuroinflammation

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The figure shows how intraneuronal Ca2+ homeostasis is regulated by channels and signaling molecules in (i) mitochondria, (ii) endoplasmic reticulum and (iii) endolysosomes.

Neuronal Ca2+ dysregulation is regarded as a key driver of neurodegeneration, but the sources from which the intracellular Ca2+ arises are still enigmatic. Project 2 examines three defined pathways in organelles that act as crucial determinants of cellular Ca2+ homeostasis: the mitochondrion, the endoplasmic reticulum (ER), and endolysosomes.