The role of transient receptor potential channels in neuroinflammation

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The figure above shows the main groups of Transient Receptor Potential (TRP) channels and the schematic conformation of a TRP channel which consists of 6 transmembrane subunits.

Project 2 examines the role of transient receptor potential vanilloid 4 channels (TRPV4) for neuroinflammation and neurodegeneration in experimental autoimmune encephalomyelitis. TRPV4 belong to the family of TRP channels which contains at least 28 members.