P2

The role of transient receptor potential channels in neuroinflammation

Click for full picture.
The figure above shows the main groups of Transient Receptor Potential (TRP) channels and the schematic conformation of a TRP channel which consists of 6 transmembrane subunits.

Project 2 examines the role of transient receptor potential vanilloid 4 channels (TRPV4) for neuroinflammation and neurodegeneration in experimental autoimmune encephalomyelitis. TRPV4 belong to the family of TRP channels which contains at least 28 members.