P5

Analysis of Ca2+-dependent signalling malfunctions in mouse models of retinal neurodegeneration and neuroinflammation

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Project 5 compares calcium signalling malfunctions in genetic models of primary retinal degeneration to those in retinal degeneration caused by autoimmune optic neuritis.

This is a timely topic because recent findings from optical coherence tomography in patients with MS have initiated a discussion about primary neurodegeneration occurring in the myelin-deficient retina independent of optic nerve pathology. In this context, the presence of more widespread neurodegeneration including retinal neurons other than retinal ganglion cells had been proposed.