P7 Role of mitochondrial calcium homeostasis in energy metabolism and neuroprotection

P7

Role of mitochondrial calcium homeostasis in energy metabolism and neuroprotection

Click for full picture.
The figure above shows single frames from a time-lapse recording of mitochondrial calcium signals in
a live retina flatmount.


Project 7 shares the rat model of optic neuritis/EAE with project 3 (Fairless/Draguhn; Neurology Heidelberg/Physiology Heidelberg) and measurement of visual function with project 1 (Diem/Flockerzi; Neurology Heidelberg/Pharmacology Homburg) in order to investigate changes in mitochondrial calcium homeostasis and its relation to neurodegeneration.

Analysing the coupling between neuronal activity and mitochondrial ATP production as proposed here is a central issue, which addresses the recent hypothesis that the signs of hypoxia in MS could effectively be the signs of energy insufficiency.