P7

Role of mitochondrial calcium homeostasis in energy metabolism and neuroprotection

Click for full picture.
The figure above shows primary rat retinal ganglion cells that have been infected with a mCherry-expressing recombinant adeno-associated virus.

Project 7 shares the rat model of optic neuritis/EAE with project 3 (Fairless/Draguhn; Neurology Heidelberg/Physiology Heidelberg) and measurement of visual function with project 1 (Diem/Flockerzi; Neurology Heidelberg/Pharmacology Homburg) in order to investigate changes in mitochondrial calcium homeostasis and its relation to neurodegeneration.

Neuronal oxygen consumption will be investigated with a newly developed method of measuring mitochondrial respiration.